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Title
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Human papillomavirus prevalence and breast carcinogenesis : a systematic review and meta-analysis of published literature
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Author
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Abstract
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| Purpose investigation: The association between human papillomavirus (HPV) infection and breast cancer remains inconclusive as detection rates of high-risk HPV in breast cancer samples are extremely variable. A meta-analysis was conducted to determine the prevalence of HPV in breast neoplasms, with emphasis on genotype distribution. Materials and Methods: A systematic literature search of MEDLINE, The Cochrane Library, and ISI Web of Science databases was conducted, ending in August 2016. A meta-analysis was performed applying the random-effects model. Sub-analyses allowed to estimate the impact of different variables on the pooled prevalence. Results: Forty studies, representing 4762 breast cancer cases, were included. The pooled prevalence of HPV in breast cancer tissue was 20% (95% confidence interval (CA) [12%;29%]). HPV prevalence in breast neoplasms varied by publication period, continental region, HPV primer design, and HPV oncogenic features. Continental region of origin determined the prevailing genotype. Conclusion: The high prevalence of HPV in breast cancer supports the hypothesis that HPV infection is involved in breast carcinogenesis. |
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Language
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English
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Source (journal)
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European journal of gynaecological oncology. - Padua
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Publication
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Montreal
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I r o g canada, inc
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2018
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ISSN
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0392-2936
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DOI
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10.12892/EJGO4068.2018
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Volume/pages
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39
:2
(2018)
, p. 161-173
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ISI
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000431622300001
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Full text (Publisher's DOI)
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