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Human papillomavirus prevalence and breast carcinogenesis : a systematic review and meta-analysis of published literature
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| Abstract |
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| Purpose investigation: The association between human papillomavirus (HPV) infection and breast cancer remains inconclusive as detection rates of high-risk HPV in breast cancer samples are extremely variable. A meta-analysis was conducted to determine the prevalence of HPV in breast neoplasms, with emphasis on genotype distribution. Materials and Methods: A systematic literature search of MEDLINE, The Cochrane Library, and ISI Web of Science databases was conducted, ending in August 2016. A meta-analysis was performed applying the random-effects model. Sub-analyses allowed to estimate the impact of different variables on the pooled prevalence. Results: Forty studies, representing 4762 breast cancer cases, were included. The pooled prevalence of HPV in breast cancer tissue was 20% (95% confidence interval (CA) [12%;29%]). HPV prevalence in breast neoplasms varied by publication period, continental region, HPV primer design, and HPV oncogenic features. Continental region of origin determined the prevailing genotype. Conclusion: The high prevalence of HPV in breast cancer supports the hypothesis that HPV infection is involved in breast carcinogenesis. |
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English
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| Source (journal) |
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European journal of gynaecological oncology. - Padua | |
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Montreal : I r o g canada, inc, 2018
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| ISSN |
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0392-2936
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| Volume/pages |
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39:2(2018), p. 161-173
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000431622300001
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| Full text (Publisher's DOI) |
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