Title
|
|
|
|
Metrics to assess the quantity of antibiotic use in the outpatient setting : a systematic review followed by an international multidisciplinary consensus procedure
| |
Author
|
|
|
|
| |
Institution/Organisation
|
|
|
|
DRIVE-AB WP1 Grp
| |
Abstract
|
|
|
|
Background: The international Innovative Medicines Initiative (IMI) project DRIVE-AB (Driving Reinvestment in Research and Development and Responsible Antibiotic Use) aims to develop a global definition of 'responsible' antibiotic use. Objectives: To identify consensually validated quantity metrics for antibiotic use in the outpatient setting. Methods: First, outpatient quantity metrics (OQMs) were identified by a systematic search of literature and web sites published until 12 December 2014. Identified OQMs were evaluated by a multidisciplinary, international stakeholder panel using a RAND-modified Delphi procedure. Two online questionnaires and a face-to-face meeting between them were conducted to assess OQM relevance for measuring the quantity of antibiotic use on a nine-point Likert scale, to add comments or to propose new metrics. Results: A total of 597 articles were screened, 177 studies met criteria for full-text screening and 138 were finally included. Twenty different OQMs were identified and appraised by 23 stakeholders. During the first survey, 14 OQMs were excluded and 6 qualified for discussion. During the face-to-face meeting, 10 stakeholders retained five OQMs and suggestions were made considering context and combination of metrics. The final set of metrics included defined daily doses, treatments/courses and prescriptions per defined population, treatments/courses and prescriptions per defined number of physician contacts and seasonal variation of total antibiotic use. Conclusions: A small set of consensually validated metrics to assess the quantity of antibiotic use in the outpatient setting was obtained, enabling (inter) national comparisons. The OQMs will help build a global conceptual framework for responsible antibiotic use. |
| |
Language
|
|
|
|
English
| |
Source (journal)
|
|
|
|
The journal of antimicrobial chemotherapy. - London, 1975, currens
| |
Publication
|
|
|
|
Oxford
:
Oxford univ press
,
2018
| |
ISSN
|
|
|
|
0305-7453
[print]
1460-2091
[online]
| |
DOI
|
|
|
|
10.1093/JAC/DKY119
| |
Volume/pages
|
|
|
|
73
:s:[6]
(2018)
, p. 59-66
| |
ISI
|
|
|
|
000434940500008
| |
Pubmed ID
|
|
|
|
29878220
| |
Full text (Publisher's DOI)
|
|
|
|
| |
Full text (open access)
|
|
|
|
| |
|