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A predictive model for risk of early grade >= 3 infection in patients with multiple myeloma not eligible for transplant: analysis of the FIRST trial
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| Abstract |
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| Infections are a major cause of death in patients with multiple myeloma. A post hoc analysis of the phase 3 FIRST trial was conducted to characterize treatment-emergent (TE) infections and study risk factors for TE grade >= 3 infection. The number of TE infections/month was highest during the first 4 months of treatment (defined as early infection). Of 1613 treated patients, 340 (21.1%) experienced TE grade >= 3 infections in the first 18 months and 56.2% of these patients experienced their first grade >= 3 infection in the first 4 months. Risk of early infection was similar regardless of treatment. Based on the analyses of data in 1378 patients through multivariate logistic regression, a predictive model of first TE grade >= 3 infection in the first 4 months retained Eastern Cooperative Oncology Group performance status and serum beta(2)-microglobulin, lactate dehydrogenase, and hemoglobin levels to define high-and low-risk groups showing significantly different rates of infection (24.0% vs. 7.0%, respectively; P < 0.0001). The predictive model was validated with data from three clinical trials. This predictive model of early TE grade >= 3 infection may be applied in the clinical setting to guide infection monitoring and strategies for infection prevention. |
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English
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Leukemia. - Baltimore, Md, 1987, currens | |
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Baltimore, Md : 2018
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0887-6924 [print]
1476-5551 [online]
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32:6(2018), p. 1404-1413
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000434474100013
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29784907
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| Full text (open access) |
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