Publication
Title
Lymphoblast-derived integration-free iPSC line AD-TREM2-1 from a 67 year-old Alzheimer's disease patient expressing the TREM2 p.R47H variant
Author
Abstract
Human lymphoblast cells from a male diagnosed with Alzheimer's disease (AD) expressing the TREM2 p.R47H variant were used to generate integration-free induced pluripotent stem cells (iPSCs) by over-expressing episomal-based plasmids harbouring OCT4, SOX2, NANOG, LIN28, c-MYC and L-MYC. AD-TREM2-1 was defined as pluripotent based on (i) expression of pluripotency-associated markers (ii) embryoid body-based differentiation into cell types representative of the three germ layers and (iii) the similarity between the transcriptome of the iPSC line and the human embryonic stem cell line H1 with a Pearson correlation of 0.947. (c) 2018 The Authors. Published by Elsevier B.V.
Language
English
Source (journal)
Stem cell research. - Place of publication unknown
Publication
Amsterdam : Elsevier science bv , 2018
ISSN
1873-5061
1876-7753
Volume/pages
29 (2018) , p. 60-63
ISI
000434978900010
Pubmed ID
29602048
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Project info
VIB-Systems biology of pathways involving brain ageing (AgedBrainSYSBIO).
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 10.07.2018
Last edited 24.08.2021
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