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Title
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Single-layer graphene modulates neuronal communication and augments membrane ion currents
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Author
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Abstract
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| The use of graphene-based materials to engineer sophisticated biosensing interfaces that can adapt to the central nervous system requires a detailed understanding of how such materials behave in a biological context. Graphenes peculiar properties can cause various cellular changes, but the underlying mechanisms remain unclear. Here, we show that single-layer graphene increases neuronal firing by altering membrane-associated functions in cultured cells. Graphene tunes the distribution of extracellular ions at the interface with neurons, a key regulator of neuronal excitability. The resulting biophysical changes in the membrane include stronger potassium ion currents, with a shift in the fraction of neuronal firing phenotypes from adapting to tonically firing. By using experimental and theoretical approaches, we hypothesize that the grapheneion interactions that are maximized when single-layer graphene is deposited on electrically insulating substrates are crucial to these effects. |
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Language
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English
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Source (journal)
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Nature nanotechnology
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Publication
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2018
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ISSN
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1748-3387
1748-3395
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DOI
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10.1038/S41565-018-0163-6
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Volume/pages
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13
:8
(2018)
, p. 755-764
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ISI
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000440842900029
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Pubmed ID
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29892019
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Full text (Publisher's DOI)
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Full text (open access)
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