Publication
Title
Single-layer graphene modulates neuronal communication and augments membrane ion currents
Author
Abstract
The use of graphene-based materials to engineer sophisticated biosensing interfaces that can adapt to the central nervous system requires a detailed understanding of how such materials behave in a biological context. Graphenes peculiar properties can cause various cellular changes, but the underlying mechanisms remain unclear. Here, we show that single-layer graphene increases neuronal firing by altering membrane-associated functions in cultured cells. Graphene tunes the distribution of extracellular ions at the interface with neurons, a key regulator of neuronal excitability. The resulting biophysical changes in the membrane include stronger potassium ion currents, with a shift in the fraction of neuronal firing phenotypes from adapting to tonically firing. By using experimental and theoretical approaches, we hypothesize that the grapheneion interactions that are maximized when single-layer graphene is deposited on electrically insulating substrates are crucial to these effects.
Language
English
Source (journal)
Nature nanotechnology
Publication
2018
ISSN
1748-3387
1748-3395
Volume/pages
13:8(2018), p. 755-764
ISI
000440842900029
Pubmed ID
29892019
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Project info
GRAPHENECORE1: Graphene-based disruptive technologies
HBP SGA1: Human Brain Project Specific Grant Agreement 1
Stochastic Assemblies in Spiking Neural Networks.
Nanodiamond labelling of neuronal cells for molecular resolution neuronal and network-level imaging
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 12.07.2018
Last edited 15.07.2021
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