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Title
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Synthesis of secondary amides from thiocarbamates
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Author
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Abstract
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| The synthesis of secondary amides from readily accessible and bench-stable substituted S-phenyl thiocarbamates and Grignard reactants is reported. Oxidative workup allows recycling of the thiolate leaving group as diphenyl disulfide. Diphenyl disulfide can be transformed into S-phenyl benzenethiosulfonate, a reactant required for thiocarbamate synthesis. This amide synthesis is suitable for the preparation of challenging amides that are not or hardly accessible via classical approaches. |
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Language
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English
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Source (journal)
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Organic letters / American Chemical Society. - Washington, D.C.
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Publication
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Washington, D.C.
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2018
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ISSN
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1523-7060
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DOI
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10.1021/ACS.ORGLETT.8B01654
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Volume/pages
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20
:14
(2018)
, p. 4235-4239
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ISI
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000439760800018
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Pubmed ID
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29975068
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Full text (Publisher's DOI)
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Full text (open access)
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