Synthesis of secondary amides from thiocarbamates
Orru, Romano V.A.
Maes, Bert U.W.
The synthesis of secondary amides from readily accessible and bench-stable substituted S-phenyl thiocarbamates and Grignard reactants is reported. Oxidative workup allows recycling of the thiolate leaving group as diphenyl disulfide. Diphenyl disulfide can be transformed into S-phenyl benzenethiosulfonate, a reactant required for thiocarbamate synthesis. This amide synthesis is suitable for the preparation of challenging amides that are not or hardly accessible via classical approaches.
Organic letters / American Chemical Society. - Washington, D.C.
20:14(2018), p. 4235-4239
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Faculty of Sciences. Chemistry
Organic synthesis (ORSY)
Durable chemical processes for the synthesis of fine chemicals.
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