Publication
Title
Synthesis of secondary amides from thiocarbamates
Author
Abstract
The synthesis of secondary amides from readily accessible and bench-stable substituted S-phenyl thiocarbamates and Grignard reactants is reported. Oxidative workup allows recycling of the thiolate leaving group as diphenyl disulfide. Diphenyl disulfide can be transformed into S-phenyl benzenethiosulfonate, a reactant required for thiocarbamate synthesis. This amide synthesis is suitable for the preparation of challenging amides that are not or hardly accessible via classical approaches.
Language
English
Source (journal)
Organic letters / American Chemical Society. - Washington, D.C.
Publication
Washington, D.C. : 2018
ISSN
1523-7060
Volume/pages
20:14(2018), p. 4235-4239
ISI
000439760800018
Pubmed ID
29975068
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Project info
Durable chemical processes for the synthesis of fine chemicals.
Development of new synthetic methods for the preparation of amidines and guanidines.
Development and use of "smart" and sustainable phosgene analogues.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 17.07.2018
Last edited 02.08.2021
To cite this reference