Publication
Title
A comprehensive overview of directing groups applied in metal-catalysed CH functionalisation chemistry
Author
Abstract
The present review is devoted to summarizing the recent advances (20152017) in the field of metal-catalysed group-directed CH functionalisation. In order to clearly showcase the molecular diversity that can now be accessed by means of directed CH functionalisation, the whole is organized following the directing groups installed on a substrate. Its aim is to be a comprehensive reference work, where a specific directing group can be easily found, together with the transformations which have been carried out with it. Hence, the primary format of this review is schemes accompanied with a concise explanatory text, in which the directing groups are ordered in sections according to their chemical structure. The schemes feature typical substrates used, the products obtained as well as the required reaction conditions. Importantly, each example is commented on with respect to the most important positive features and drawbacks, on aspects such as selectivity, substrate scope, reaction conditions, directing group removal, and greenness. The targeted readership are both experts in the field of CH functionalisation chemistry (to provide a comprehensive overview of the progress made in the last years) and, even more so, all organic chemists who want to introduce the CH functionalisation way of thinking for a design of straightforward, efficient and step-economic synthetic routes towards molecules of interest to them. Accordingly, this review should be of particular interest also for scientists from industrial R&D sector. Hence, the overall goal of this review is to promote the application of CH functionalisation reactions outside the research groups dedicated to method development and establishing it as a valuable reaction archetype in contemporary R&D, comparable to the role cross-coupling reactions play to date.
Language
English
Source (journal)
Chemical Society reviews. - London
Chemical Society reviews. - London
Publication
Cambridge : Royal soc chemistry , 2018
ISSN
0306-0012
Volume/pages
47 :17 (2018) , p. 6603-6743
ISI
000443171000012
Pubmed ID
30033454
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Project info
Bio based factory: Sustainable chemistry from wood (BioFact).
FarCatCH: Innovative Strategies for Unprecedented Remote C-H bond Functionalization by Catalysis
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 25.07.2018
Last edited 20.09.2021
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