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Title
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Adaptive nocturnal seizure detection using heart rate and low-complexity novelty detection
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Author
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Abstract
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| Purpose: Automated seizure detection at home is mostly done using either patient-independent algorithms or manually personalized algorithms. Patient-independent algorithms, however, lead to too many false alarms, whereas the manually personalized algorithms typically require manual input from an experienced clinician for each patient, which is a costly and unscalable procedure and it can only be applied when the patient had a sufficient amount of seizures. We therefore propose a nocturnal heart rate based seizure detection algorithm that automatically adapts to the patient without requiring seizure labels. Methods: The proposed method initially starts with a patient-independent algorithm. After a very short initialization period, the algorithm already adapts to the patients' characteristics by using a low-complex novelty detection classifier. The algorithm is evaluated on 28 pediatric patients with 107 convulsive and clinical subtle seizures during 695 h of nocturnal multicenter data in a retrospective study that mimics a real-time analysis. Results: By using the adaptive seizure detection algorithm, the overall performance was 77.6% sensitivity with on average 2.56 false alarms per night. This is 57% less false alarms than a patient-independent algorithm with a similar sensitivity. Patients with tonic-clonic seizures showed a 96% sensitivity with on average 1.84 false alarms per night. Conclusion: The proposed method shows a strongly improved detection performance over patient independent performance, without requiring manual adaptation by a clinician. Due to the low-complexity of the algorithm, it can be easily implemented on wearables as part of a (multimodal) seizure alarm system. (C) 2018 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved. |
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Language
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English
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Source (journal)
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Seizure: European journal of epilepsy. - London
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Publication
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London
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2018
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ISSN
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1059-1311
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DOI
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10.1016/J.SEIZURE.2018.04.020
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Volume/pages
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59
(2018)
, p. 48-53
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ISI
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000437818500010
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Pubmed ID
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29747021
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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