Publication
Title
The role of the common gamma-chain family cytokines in T cell-based anti-cancer immunotherapy
Author
Abstract
Cytokines of the common gamma-chain receptor family, comprising interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15 and IL-21, are vital with respect to organizing and sustaining healthy immune cell functions. Supporting the anticancer immune response, these cytokines inspire great interest for their use as vaccine adjuvants and cancer immunotherapies. It is against this background that gamma delta (gamma delta) T cells, as special-force soldiers and natural contributors of the tumor immunosurveillance, also received a lot of attention the last decade. As gamma delta T cell-based cancer trials are coming of age, this present review focusses on the effects of the different cytokines of the common gamma-chain receptor family on gamma delta T cells with respect to boosting gamma delta T cells as a therapeutic target in cancer immunotherapy. This review also gathers data that IL-15 in particular exhibits key features for augmenting the anti-tumor activity of effector killer gamma delta T cells whilst overcoming the myriad of immune escape mechanisms used by cancer cells.
Language
English
Source (journal)
Cytokine and growth factor reviews. - Oxford
Publication
Oxford : Elsevier sci ltd, 2018
ISSN
1359-6101
Volume/pages
41(2018), p. 54-64
ISI
000437776600006
Pubmed ID
29773448
Full text (Publisher's DOI)
Full text (open access)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Project info
CD56+ human blood dendritic cells: unique mediators of strong natural killer and gamma-delta T cell activation to promote antigen-specific T cell immune responses in health and disease.
Maximizing the anti-tumor potency of next-generation dendritic cell vaccines by combining interleukin-15 and in situ silencing of programmed-death ligands.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 02.08.2018
Last edited 15.07.2021
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