Publication
Title
Intravenous fluid therapy for hospitalized and critically ill children: rationale, available drugs and possible side effects
Author
Abstract
Human beings are constituted mainly of water. In particular, children's total body water might reach 75-80% of their body weight, compared to 60-70% in adults. It is therefore not surprising, that children, especially hospitalized new-borns and infants, are markedly prone to water and electrolyte imbalances. Parenteral fluid therapy is a cornerstone of medical treatment and is thus of exceptional relevance in this patient population. It is crucial to appreciate the fact that intravenous fluids are drugs with very different characteristics, different indications, contraindications and relevant side effects. In the present review, we will summarize the physiology and pathophysiology of water and electrolyte balance, underlining the importance and high prevalence of non-osmotic antidiuretic hormone release in hospitalized and critically ill children. Furthermore, we will discuss the characteristics and potential side effects of available crystalloids for the paediatric population, making a clear distinction between fluids that are hypotonic or isotonic as compared to normal plasma. Finally, we will review the current clinical practice regarding the use of different parenteral fluids in children, outlining both the current consensus on fluids employed for resuscitation and replacement and the ongoing debate concerning parenteral maintenance fluids.
Language
English
Source (journal)
Anaesthesiology Intesive Therapy / Polskie Towarzystwo Anestezjologii i Intensywnej Terapii. - Warsaw, 2001, currens
Publication
Gdansk : Via medica , 2018
ISSN
1731-2531
1642-5758
Volume/pages
50 :1 (2018) , p. 49-58
ISI
000436858800008
Pubmed ID
29151001
Full text (Publisher's DOI)
UAntwerpen
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 02.08.2018
Last edited 11.09.2021
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