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Title
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Contact allergy caused by isothiazolinone derivatives : an overview of non-cosmetic and unusual cosmetic sources
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Author
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Abstract
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| The isothiazolinone derivatives, methylchloroisothiazolinone (MCI), methylisothiazolinone (MI), benzisothiazolinone (BIT), and octylisothiazolinone (OIT), owing to their strong bactericide, fungicide and algicide properties, are widely used in non-cosmetic products, such as chemical (industrial) products, household detergents, and water-based paints, and the former two derivatives are also used in cosmetic products. However, given their inherent sensitization potential (with MCI > MI > BIT > OIT), allergic contact dermatitis is frequently observed, both in consumers as well as workers in various industries. In this review, we provide an update on the use of MCI/MI and MI in cosmetics, highlighting certain aspects of MI; the use of excessive concentrations, the presence in some less familiar cosmetic products, and the association with unusual clinical manifestations. Furthermore, the use of isothiazolinones in dish-washing and washing-machine liquids, cleaning agents for dental care, and their general presence in multi-purpose household detergents, which may elicit (airborne) allergic contact dermatitis, is discussed. Finally, we provide a brief overview of the use of isothiazolinone derivatives in the paint and textile industry, and of OIT in the leather industry in particular. |
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Language
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English
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Source (journal)
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European journal of dermatology. - Montrouge, 1991, currens
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Publication
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Montrouge
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John libbey eurotext ltd
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2017
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ISSN
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1167-1122
[print]
1952-4013
[online]
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DOI
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10.1684/EJD.2016.2951
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Volume/pages
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27
:2
(2017)
, p. 115-122
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ISI
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000400143700001
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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