Publication
Title
Impact of plasma oxidation on structural features of human epidermal growth factor
Author
Abstract
We perform computer simulations supported by experiments to investigate the oxidation of an important signaling protein, that is, human epidermal growth factor (hEGF), caused by cold atmospheric plasma (CAP) treatment. Specifically, we study the conformational changes of hEGF with different degrees of oxidation, to mimic short and long CAP treatment times. Our results indicate that the oxidized structures become more flexible, due to their conformational changes and breakage of the disulfide bonds, especially at higher oxidation degrees. MM/GBSA calculations reveal that an increasing oxidation level leads to a lower binding free energy of hEGF with its receptor. These results help to understand the fundamentals of the use of CAP for wound healing versus cancer treatment at short and longer treatment times.
Language
English
Source (journal)
Plasma processes and polymers. - Weinheim
Plasma processes and polymers. - Weinheim
Publication
Weinheim : 2018
ISSN
1612-8850
Volume/pages
15 :8 (2018) , 10 p.
Article Reference
1800022
e1800022
ISI
000441895700004
Medium
E-only publicatie
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Project info
Atomic scale modeling for plasma cancer treatment.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 20.08.2018
Last edited 19.10.2021
To cite this reference