Publication
Title
Systematic review of cognitive event related potentials in euthymic bipolar disorder
Author
Abstract
Cognitive deficits are critical features of bipolar disorder (BD), greatly impacting quality of life. The aim is to systematically review and critically evaluate underlying event related potential (ERP) features in euthymic BD relating to differences in sensory processes, attention, inhibition and conflict monitoring compared with healthy controls. 911 unique articles were identified using the PubMed database and 14 studies met the inclusion criteria. Individuals with BD in a euthymic state have reduced P50 sensory gating and reduced P100 amplitudes compared with healthy controls. Many studies demonstrated reduced P300 amplitudes and normal P300 latencies in BD. In addition, reduced NoGo N2 and abnormal NoGo P3 activity were observed in BD. Finally, there is some evidence of reduced error-related negativity amplitudes in BD. Importantly, ERP modulations vary with stimulus factors and clinical profile. The functional significance of these findings and clinical implications are discussed. ERP differences in BD arise at various stages of cognitive processing, specifically in early auditory and visual processing, attention allocation, context updating, inhibition and conflict monitoring. Treating these deficits and their underlying neurobiological disturbances corresponding to abnormal performance on cognitive tasks may aid functional remission. This knowledge might enable personalized treatment interventions targeting specific cognitive deficits.
Language
English
Source (journal)
Clinical neurophysiology. - Amsterdam
Clinical neurophysiology. - Amsterdam
Publication
Clare : Elsevier ireland ltd , 2018
ISSN
1388-2457
Volume/pages
129 :9 (2018) , p. 1854-1865
ISI
000440658200009
Pubmed ID
29981961
Full text (Publisher's DOI)
Full text (open access)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 04.09.2018
Last edited 18.11.2021
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