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Title
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Optimizing treatments for recurrent or metastatic head and neck squamous cell carcinoma
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Author
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Abstract
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| Introduction: The majority of patients with locally advanced head and neck squamous cell carcinoma (HNSCC) will recur. The treatment of patients with recurrent/metastatic (R/M HNSCC) is rapidly evolving.Areas covered: This article will comprehensively review the current systemic treatment of R/M HNSCC.Expert commentary: For the time being, the EXTREME regimen (cetuximab in combination with platinum and 5-fluorouracil) still remains standard of care in previously untreated R/M HNSCC patients who are candidates for combination chemotherapy. Single agents with well documented activity in HNSCC include methotrexate, cisplatin, 5-FU, docetaxel, and paclitaxel. The anti-PD-1 monoclonal antibody nivolumab can be considered the current standard of care in patients with R/M HNSCC progressing after platinum-based therapy based on the results of CheckMate 141 showing a survival benefit over standard of care drugs, such as single agent weekly cetuximab, methotrexate, or docetaxel.Multiple randomized phase III trials comparing anti-PD(L)-antibodies either as single agent or in combination with chemotherapy or an anti-CTLA-4 with the EXTREME as fist line treatment are ongoing or planned. The outcome of these trials might change the current treatment paradigm in previously untreated R/M HNSCC. Immunotherapeutic agents under active investigation include Toll-like receptor 8 agonists and inhibitors of IDO1. |
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Language
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English
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Source (journal)
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Expert review of anticancer therapy
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Publication
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Abingdon
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Taylor & francis ltd
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2018
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ISSN
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1473-7140
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Volume/pages
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18
:9
(2018)
, p. 901-915
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ISI
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000441639700007
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Pubmed ID
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29999437
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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