Publication
Title
Peripheral and respiratory muscles in chronic heart failure
Author
Abstract
It is well-established that in patients with congestive heart failure (CHF), exercise is limited by fatigue and shortness of breath. The poor correlation between the fatigue and indices of central haemodynamic function might indicate that peripheral muscle alterations contribute to impaired exercise capacity. Intrinsic abnormalities of the skeletal muscles have been suggested as a possible explanation. Since the shortness of breath correlates poorly with changes in lung function, changes in the respiratory muscles have been investigated. Studies have demonstrated diaphragmatic myopathy and atrophy similar, in part, to the changes in peripheral skeletal muscles. In CHF, type I (slow twitch) fibre atrophy is seen in respiratory as well as in peripheral muscles. The mechanism of these alterations remains to be elucidated. Studies into the mechanism of muscle dysfunction in congestive heart failure are relevant to the prospect of treatment of the changes in peripheral and respiratory muscles.
Language
English
Source (journal)
The European respiratory journal / European Respiratory Society [Lausanne] - Copenhagen, 1988, currens
Publication
Copenhagen : 1996
ISSN
0903-1936 [print]
1399-3003 [online]
Volume/pages
9 :10 (1996) , p. 2161-2167
ISI
A1996VL73700033
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 20.09.2018
Last edited 11.09.2021