Publication
Title
Cellular senescence links aging and diabetes in cardiovascular disease
Author
Abstract
Aging is a powerful independent risk factor for cardiovascular diseases such as atherosclerosis and heart failure. Concomitant diabetes mellitus strongly reinforces this effect of aging on cardiovascular disease. Cellular senescence is a fundamental mechanism of aging and appears to play a crucial role in the onset and prognosis of cardiovascular disease in the context of both aging and diabetes. Senescent cells are in a state of cell cycle arrest but remain metabolically active by secreting inflammatory factors. This senescence-associated secretory phenotype is a trigger of chronic inflammation, oxidative stress, and decreased nitric oxide bioavailability. A complex interplay between these three mechanisms results in age-and diabetes-associated cardiovascular damage. In this review, we summarize current knowledge on cellular senescence and its secretory phenotype, which might be the missing link between aging and diabetes contributing to cardiovascular disease.
Language
English
Source (journal)
American journal of physiology: heart and circulatory physiology. - Bethesda, Md
Publication
Bethesda : Amer physiological soc , 2018
ISSN
0363-6135
0363-6135
Volume/pages
315 :3 (2018) , p. 448-462
ISI
000444288600002
Pubmed ID
29750567
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Project info
Identification of small molecule ErbB4 agonists for treatment of heart failure.
Rol of growth factor signaling in age-related cardiovascular impairment.
INFLA-MED - Fundamental research in the pathophysiological processes of inflammatory diseases.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 08.10.2018
Last edited 20.09.2021
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