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Flavonoids from Boldoa purpurascens inhibit proinflammatory cytokines (TNF- and IL-6) and the expression of COX-2
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| Abstract |
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| The flavonoids comprise a large class of plant metabolites distributed in food plants. These compounds have antioxidant, antitumor, antiallergic, and anti-inflammatory effects. The molecular mechanisms of their biological activities remain to be clearly understood. We investigated the in vitro anti-inflammatory potential of a flavonoid mixture and isolated compounds from the leaves of Boldoa purpurascens. Our results provide direct evidence of the anti-inflammatory effects of the mixture, which are mediated by the inhibition of the proinflammatory cytokines tumor necrosis factor and interleukin 6 as well as the modulation of the expression of cyclooxygenase 2. |
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English
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| Source (journal) |
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Phytotherapy research. - London |
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London : 2018
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0951-418X
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32:9(2018), p. 1750-1754
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| ISI |
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000443811500009
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| Full text (open access) |
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| Full text (publisher's version - intranet only) |
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