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Title
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Flavonoids from Boldoa purpurascens inhibit proinflammatory cytokines (TNF- and IL-6) and the expression of COX-2
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Author
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Abstract
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| The flavonoids comprise a large class of plant metabolites distributed in food plants. These compounds have antioxidant, antitumor, antiallergic, and anti-inflammatory effects. The molecular mechanisms of their biological activities remain to be clearly understood. We investigated the in vitro anti-inflammatory potential of a flavonoid mixture and isolated compounds from the leaves of Boldoa purpurascens. Our results provide direct evidence of the anti-inflammatory effects of the mixture, which are mediated by the inhibition of the proinflammatory cytokines tumor necrosis factor and interleukin 6 as well as the modulation of the expression of cyclooxygenase 2. |
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Language
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English
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Source (journal)
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Phytotherapy research. - London
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Publication
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London
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2018
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ISSN
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0951-418X
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Volume/pages
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32
:9
(2018)
, p. 1750-1754
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ISI
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000443811500009
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Full text (Publisher's DOI)
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Full text (open access)
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Full text (publisher's version - intranet only)
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