Publication
Title
Flavonoids from Boldoa purpurascens inhibit proinflammatory cytokines (TNF- and IL-6) and the expression of COX-2
Author
Abstract
The flavonoids comprise a large class of plant metabolites distributed in food plants. These compounds have antioxidant, antitumor, antiallergic, and anti-inflammatory effects. The molecular mechanisms of their biological activities remain to be clearly understood. We investigated the in vitro anti-inflammatory potential of a flavonoid mixture and isolated compounds from the leaves of Boldoa purpurascens. Our results provide direct evidence of the anti-inflammatory effects of the mixture, which are mediated by the inhibition of the proinflammatory cytokines tumor necrosis factor and interleukin 6 as well as the modulation of the expression of cyclooxygenase 2.
Language
English
Source (journal)
Phytotherapy research. - London
Publication
London : 2018
ISSN
0951-418X
DOI
10.1002/PTR.6104
Volume/pages
32 :9 (2018) , p. 1750-1754
ISI
000443811500009
Full text (Publisher's DOI)
Full text (open access)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 08.10.2018
Last edited 28.01.2024
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