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Title
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A systematic review comparing the diagnostic value of 14-3-3 protein in the cerebrospinal fluid, RT-QuIC and RT-QuIC on nasal brushing in sporadic Creutzfeldt-Jakob disease
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Author
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Abstract
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| Sporadic Creutzfeldt-Jakob disease (sCJD) is a human prion disease that is a relatively common differential diagnosis in dementia patients. Therefore it needs a good diagnostic tool. Brain autopsy is the golden standard for the diagnosis of CJD; however, a less invasive technique is 14-3-3 protein measurement in the cerebrospinal fluid (CSF). In this systematic review, we compared the diagnostic value of the 14-3-3 protein measurement to the newer RT-QuIC test and a variant of RT-QuIC where nasal brushing is used to collect the samples. The search via MeSH terms and quality assessment was carried out by two individual researchers. In 14-3-3 and RT-QuIC the sensitivity was comparable, respectively, 88% and 86%. Specificity however was higher in RT-QuIC 99.5% compared to 80% in 14-3-3. Nasal brushing showed the best results with a sensitivity of 97% and a specificity of 100%. Nasal brushing, despite being the best diagnostic tool according to the data, needs more study since there has only been a few studies regarding the technique. It is safe to say that due to the high specificity, RT-QuIC is superior to 14-3-3 testing. |
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Language
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English
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Source (journal)
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Acta neurologica Belgica. - Bruxelles
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Publication
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Heidelberg
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Springer heidelberg
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2018
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ISSN
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0300-9009
[print]
2240-2993
[online]
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Volume/pages
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118
:3
(2018)
, p. 395-403
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ISI
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000442249600007
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Pubmed ID
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30097826
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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