Publication
Title
Adrenergically and non-adrenergically mediated human adipose tissue lipolysis during acute exercise and exercise training
Author
Abstract
Obesity-related adipose tissue (AT) dysfunction, in particular subcutaneous AT (SCAT) lipolysis, is characterized by catecholamine resistance and impaired atrial natriuretic peptide (ANP) responsiveness. It remains unknown whether exercise training improves (non-)adrenergically mediated lipolysis in metabolically compromised conditions. We investigated the effects of local combined alpha-/beta-adrenoceptor blockade on abdominal SCAT lipolysis in lean insulin sensitive (IS) (n = 10), obese IS (n = 10), and obese insulin resistant (IR) (n = 10) men. Obese men participated in a 12-week exercise training intervention to determine the effects on SCAT lipolysis. Abdominal SCAT extracellular glycerol concentration and blood flow (ATBF) were investigated using microdialysis, with/without locally combined alpha-/beta-adrenoceptor blockade at rest, during low-intensity endurance-type exercise and post-exercise recovery. In obese IR men, microdialysis was repeated after exercise intervention. The exercise-induced increase in SCAT extracellular glycerol was more pronounced in obese IS compared with lean IS men, possibly resulting from lower ATBF in obese IS men. The exercise-induced increase in extracellular glycerol was blunted in obese IR compared with obese IS men, despite comparable local ATBF. Abdominal SCAT extracellular glycerol was markedly reduced (remaining similar to 60% of exercise-induced SCAT extracellular glycerol) following the local alpha-/beta-adrenoceptor blockade in obese IS but not in IR men, suggesting reduced catecholamine mediated lipolysis during exercise in obese IR men. Exercise training did not affect (non-) adrenergically mediated lipolysis in obese IR men. Our findings showed a major contribution of non-adrenergically-mediated lipolysis during exercise in male abdominal SCAT. Furthermore, catecholamine mediated lipolysis may be blunted during exercise in obese IR men but could not be improved by exercise intervention, despite an improved metabolic profile and body composition.
Language
English
Source (journal)
Clinical science. - Colchester
Publication
Colchester : 2018
ISSN
0143-5221
0009-9287
Volume/pages
132 :15 (2018) , p. 1685-1698
ISI
000443723100004
Pubmed ID
29980605
Full text (Publisher's DOI)
Full text (open access)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 08.10.2018
Last edited 26.09.2021
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