Publication
Title
The effect of maternal vitamin D status on pregnancy outcome and child health in the first year of life
Author
Abstract
Aim: To study the relationship of maternal vitamin D level at the moment of delivery with gestational and infant outcomes. Materials and Methods: A single centre prospective cohort study. Main outcomes were birth weight percentile and respiratory tract infections in the first year, secondary outcomes gestational diabetes, preterm birth, pre-eclampsia, caesarean birth, and atopic dermatitis and gastroenteritis in the first year of life. Maternal vitamin D was determined in venous plasma after delivery, infant data were prospectively gathered through a diary kept by the parents. Results: A total of 240 deliveries was included. Vitamin D insufficiency was present in the large majority (n= 205, 95.5%) In univariate analysis a significant association was found between vitamin D level < 10 ng/ml and birthweight < P10, but in multivariate analysis including parity, maternal age, fetal sex, gestational diabetes, maternal glucose level, and preeclampsia there was no significant contribution from low vitamin D. For only 37 (15%) infants complete follow up data for one year were available. An association was found between lower vitamin D and more than two respiratory tract infections; this relations disappeared when taking into account birthweight, breastfeeding, and having a sibling going to daycare. No relation was present between vitamin D and pre-eclampsia, caesarean birth, atopic dermatitis, and gastroenteritis. Conclusions: The actual cut off values for vitamin D should be questioned as over 90% of the population would be deficient. When considering other factors, maternal vitamin D at the moment of delivery does not correlate with birthweight percentile, respiratory tract infections in the first year of life, nor other frequent obstetric and infant problems.
Language
English
Source (journal)
Clinical and experimental obstetrics and gynecology. - Padua
Publication
Padua : 2018
ISSN
0390-6663
Volume/pages
45:5(2018), p. 677-681
ISI
000444385100007
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 08.10.2018
Last edited 24.07.2021
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