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Title
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Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue
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Author
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Abstract
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| Hair follicles are unique organs undergoing regular cycles of proliferation, differentiation, and apoptosis. The final step of apoptosis is, in general, mediated by executioner caspases comprising caspase-3, -6 and -7. Despite their commonly accepted apoptotic function, executioner caspases also participate in non-apoptotic processes. In the present study, we investigated activation (cleavage) of caspase-7 in mouse hair follicles and surrounding tissue during embryonic development into adulthood. Casp7 (-/-) mice were examined to understand the effect of caspase-7 deficiency in the skin. The activated form of caspase-7 was observed during embryonic hair follicle development, as well as in the first hair cycle. In general, activation of caspase-7 did not correlate with apoptosis and activation of caspase-3, except during physiological hair follicle regression. Notably, cleaved caspase-7 was observed in mast cells and its deficiency in the adult skin resulted in increased mast cell number. Our study shows for the first time activated caspase-7 in hair follicles and mast cells and indicates its non-apoptotic roles in the skin. |
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Language
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English
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Source (journal)
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Journal of molecular histology. - Dordrecht, 2004, currens
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Publication
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Dordrecht
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2015
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ISSN
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1567-2379
[print]
1567-2387
[online]
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Volume/pages
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46
:4-5
(2015)
, p. 443-455
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ISI
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000359823900013
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Full text (Publisher's DOI)
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