|
Title
|
|
|
|
Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue
| |
|
Author
|
|
|
|
| |
|
Abstract
|
|
|
|
| Hair follicles are unique organs undergoing regular cycles of proliferation, differentiation, and apoptosis. The final step of apoptosis is, in general, mediated by executioner caspases comprising caspase-3, -6 and -7. Despite their commonly accepted apoptotic function, executioner caspases also participate in non-apoptotic processes. In the present study, we investigated activation (cleavage) of caspase-7 in mouse hair follicles and surrounding tissue during embryonic development into adulthood. Casp7 (-/-) mice were examined to understand the effect of caspase-7 deficiency in the skin. The activated form of caspase-7 was observed during embryonic hair follicle development, as well as in the first hair cycle. In general, activation of caspase-7 did not correlate with apoptosis and activation of caspase-3, except during physiological hair follicle regression. Notably, cleaved caspase-7 was observed in mast cells and its deficiency in the adult skin resulted in increased mast cell number. Our study shows for the first time activated caspase-7 in hair follicles and mast cells and indicates its non-apoptotic roles in the skin. |
| |
|
Language
|
|
|
|
English
| |
|
Source (journal)
|
|
|
|
Journal of molecular histology. - Dordrecht, 2004, currens
| |
|
Publication
|
|
|
|
Dordrecht
:
2015
| |
|
ISSN
|
|
|
|
1567-2379
[print]
1567-2387
[online]
| |
|
DOI
|
|
|
|
10.1007/S10735-015-9636-1
| |
|
Volume/pages
|
|
|
|
46
:4-5
(2015)
, p. 443-455
| |
|
ISI
|
|
|
|
000359823900013
| |
|
Full text (Publisher's DOI)
|
|
|
|
| |
|