Publication
Title
Regulated necrosis : the expanding network of non-apoptotic cell death pathways
Author
Abstract
Cell death research was revitalized by the understanding that necrosis can occur in a highly regulated and genetically controlled manner. Although RIPK1 (receptor-interacting protein kinase 1)- and RIPK3-MLKL (mixed lineage kinase domain-like)-mediated necroptosis is the most understood form of regulated necrosis, other examples of this process are emerging, including cell death mechanisms known as parthanatos, oxytosis, ferroptosis, NETosis, pyronecrosis and pyroptosis. Elucidating how these pathways of regulated necrosis are interconnected at the molecular level should enable this process to be therapeutically targeted.
Language
English
Source (journal)
Nature reviews : molecular cell biology. - London, 2000, currens
Publication
London : Nature Publishing Group , 2014
ISSN
1471-0072 [print]
1471-0080 [online]
Volume/pages
15 :2 (2014) , p. 135-147
ISI
000330190100012
Full text (Publisher's DOI)
UAntwerpen
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 18.10.2018
Last edited 28.08.2021