Publication
Title
Caspase-7 participates in differentiation of cells forming dental hard tissues
Author
Abstract
Apoptosis during tooth development appears dependent on the apoptotic executioner caspase-3, but not caspase-7. Instead, activated caspase-7 has been found in differentiated odontoblasts and ameloblasts, where it does not correlate with apoptosis. To further investigate these findings, the mouse incisor was used as a model. Analysis of caspase-7-deficient mice revealed a significant thinner layer of hard tissue in the adult incisor. Micro computed tomography scan confirmed this decrease in mineralized tissues. These data strongly suggest that caspase-7 might be directly involved in functional cell differentiation and regulation of the mineralization of dental matrices.
Language
English
Source (journal)
Development, growth and differentiation. - Nagoya
Publication
Nagoya : 2013
ISSN
0012-1592
Volume/pages
55:5(2013), p. 615-621
ISI
000320470700003
Full text (Publisher's DOI)
UAntwerpen
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 18.10.2018
Last edited 06.07.2021