|
Title
|
|
|
|
Caspase-7 participates in differentiation of cells forming dental hard tissues
| |
|
Author
|
|
|
|
| |
|
Abstract
|
|
|
|
| Apoptosis during tooth development appears dependent on the apoptotic executioner caspase-3, but not caspase-7. Instead, activated caspase-7 has been found in differentiated odontoblasts and ameloblasts, where it does not correlate with apoptosis. To further investigate these findings, the mouse incisor was used as a model. Analysis of caspase-7-deficient mice revealed a significant thinner layer of hard tissue in the adult incisor. Micro computed tomography scan confirmed this decrease in mineralized tissues. These data strongly suggest that caspase-7 might be directly involved in functional cell differentiation and regulation of the mineralization of dental matrices. |
| |
|
Language
|
|
|
|
English
| |
|
Source (journal)
|
|
|
|
Development, growth and differentiation. - Nagoya
| |
|
Publication
|
|
|
|
Nagoya
:
2013
| |
|
ISSN
|
|
|
|
0012-1592
| |
|
Volume/pages
|
|
|
|
55
:5
(2013)
, p. 615-621
| |
|
ISI
|
|
|
|
000320470700003
| |
|
Full text (Publisher's DOI)
|
|
|
|
| |
|