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Title
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Caspase-7 participates in differentiation of cells forming dental hard tissues
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Author
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Abstract
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| Apoptosis during tooth development appears dependent on the apoptotic executioner caspase-3, but not caspase-7. Instead, activated caspase-7 has been found in differentiated odontoblasts and ameloblasts, where it does not correlate with apoptosis. To further investigate these findings, the mouse incisor was used as a model. Analysis of caspase-7-deficient mice revealed a significant thinner layer of hard tissue in the adult incisor. Micro computed tomography scan confirmed this decrease in mineralized tissues. These data strongly suggest that caspase-7 might be directly involved in functional cell differentiation and regulation of the mineralization of dental matrices. |
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Language
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English
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Source (journal)
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Development, growth and differentiation. - Nagoya
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Publication
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Nagoya
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2013
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ISSN
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0012-1592
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DOI
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10.1111/DGD.12066
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Volume/pages
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55
:5
(2013)
, p. 615-621
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ISI
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000320470700003
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Full text (Publisher's DOI)
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