Publication
Title
Interaction patches of Procaspase-1 Caspase Recruitment Domains (CARDs) are differently involved in Procaspase-1 Activation and Receptor-interacting Protein 2 (RIP2)-dependent nuclear factor κB signaling
Author
Abstract
Background: The CARD of procaspase-1 regulates activation of procaspase-1 and NF-kappa B. Results: We show that the CARD procaspase-1 interacts with ASC through a type I interaction, whereas RIP2-mediated NF-kappa B activation involves a type III interaction. Conclusion: These findings indicate that the CARD of procaspase-1 is differently involved in inflammasome formation and NF-kappa B activation. Significance: These findings may allow development of therapeutics that specifically target a procaspase-1 function.
Language
English
Source (journal)
Journal of biological chemistry. - Baltimore, Md
Publication
Baltimore, Md : 2011
ISSN
0021-9258 [print]
1083-351X [online]
Volume/pages
286 :41 (2011) , p. 35874-35882
ISI
000295927100060
Full text (Publisher's DOI)
UAntwerpen
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 18.10.2018
Last edited 06.09.2021