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Title
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Interaction patches of Procaspase-1 Caspase Recruitment Domains (CARDs) are differently involved in Procaspase-1 Activation and Receptor-interacting Protein 2 (RIP2)-dependent nuclear factor κB signaling
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Author
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Abstract
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| Background: The CARD of procaspase-1 regulates activation of procaspase-1 and NF-kappa B. Results: We show that the CARD procaspase-1 interacts with ASC through a type I interaction, whereas RIP2-mediated NF-kappa B activation involves a type III interaction. Conclusion: These findings indicate that the CARD of procaspase-1 is differently involved in inflammasome formation and NF-kappa B activation. Significance: These findings may allow development of therapeutics that specifically target a procaspase-1 function. |
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Language
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English
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Source (journal)
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Journal of biological chemistry. - Baltimore, Md
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Publication
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Baltimore, Md
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2011
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ISSN
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0021-9258
[print]
1083-351X
[online]
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DOI
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10.1074/JBC.M111.242321
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Volume/pages
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286
:41
(2011)
, p. 35874-35882
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ISI
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000295927100060
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Full text (Publisher's DOI)
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