Publication
Title
Necrotic cell death and 'necrostatins' : now we can control cellular explosion
Author
Abstract
The receptor-interacting protein 1 (RIP1) kinase activity is necessary for death-receptor-induced necrotic cell death. Recently, it has been demonstrated that 'necrostatins' efficiently block tumor necrosis factor-induced necrotic cell death through the inhibition of RIP1 kinase activity. This discovery supports the concept that receptor-induced necrosis, just like apoptosis, is a controlled cellular process. In addition, necrostatins are becoming important tools for evaluating the contribution of necrotic cell death in experimental disease models.
Language
English
Source (journal)
Trends in biochemical sciences. - Amsterdam
Publication
Amsterdam : 2008
ISSN
0968-0004
0376-5067 [Reference edition]
Volume/pages
33:8(2008), p. 352-355
ISI
000258817000002
Full text (Publisher's DOI)
UAntwerpen
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 18.10.2018
Last edited 29.08.2021