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Title
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Necrotic cell death and 'necrostatins' : now we can control cellular explosion
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Author
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Abstract
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| The receptor-interacting protein 1 (RIP1) kinase activity is necessary for death-receptor-induced necrotic cell death. Recently, it has been demonstrated that 'necrostatins' efficiently block tumor necrosis factor-induced necrotic cell death through the inhibition of RIP1 kinase activity. This discovery supports the concept that receptor-induced necrosis, just like apoptosis, is a controlled cellular process. In addition, necrostatins are becoming important tools for evaluating the contribution of necrotic cell death in experimental disease models. |
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Language
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English
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Source (journal)
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Trends in biochemical sciences. - Amsterdam
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Publication
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Amsterdam
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2008
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ISSN
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0968-0004
0376-5067
[Reference edition]
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DOI
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10.1016/J.TIBS.2008.05.007
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Volume/pages
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33
:8
(2008)
, p. 352-355
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ISI
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000258817000002
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Full text (Publisher's DOI)
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