Publication
Title
Synthesis of Pd complexes containing tailed NHC ligands and their use in a semicontinuous membrane-assisted Suzuki cross-coupling process
Author
Abstract
Homogeneous catalysis has proved to be a reliable method for preparing numerous molecular entities, but catalysts can be expensive and difficult to remove. Because of this, industry targets catalysts that are easily separated and recovered and feature increased turnover numbers. The ongoing shift from multipurpose batch reactors toward continuous manufacturing in fine chemicals synthesis results in a new set of catalyst requirements. This paper reports the design and use of Pd complexes suitable for a semicontinuous Suzuki cross-coupling reaction based on a membrane-assisted reactor. These Pd complexes contain tailed N-heterocyclic carbene (NHC) ligands, allowing internal catalyst recovery by organic solvent nanofiltration with top-layer-modified ceramic membranes. These membranes give selective nanofiltration of the catalyst based on a combination of size exclusion and affinity separation (solventsolutemembrane interactions). The semicontinuous system developed led to significantly improved turnover numbers, simplified product isolation, and consequently reduced mass intensity by simply adding more of the reactants and reagents to the reaction vessel.
Language
English
Source (journal)
Organic process research and development. - -
Publication
2018
ISSN
1083-6160
Volume/pages
22:11(2018), p. 1509-1517
ISI
000451100700005
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Project info
FunMem4Affinity: Exploration of functional ceramic membranes for affinity organic solvent nanofiltration.
Chemical Manufacturing Methods for the 21st Century Pharmaceuticals Industries (CHEM21).
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 29.10.2018
Last edited 16.07.2021
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