Publication
Title
Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome
Author
Abstract
Aortic aneurysm and dissection are manifestations of Marfan syndrome (MFS), a disorder caused by mutations in the gene that encodes fibrillin-1. Selected manifestations of MFS reflect excessive signaling by the transforming growth factor-beta (TGF-beta) family of cytokines. We show that aortic aneurysm in a mouse model of MFS is associated with increased TGF-beta signaling and can be prevented by TGF-beta antagonists such as TGF-beta-neutralizing antibody or the angiotensin II type 1 receptor (AT1) blocker, losartan. AT1 antagonism also partially reversed noncardiovascular manifestations of MFS, including impaired alveolar septation. These data suggest that losartan, a drug already in clinical use for hypertension, merits investigation as a therapeutic strategy for patients with MFS and has the potential to prevent the major life-threatening manifestation of this disorder.
Language
English
Source (journal)
Science / American Association for the Advancement of Science [Washington, D.C.] - Washington, D.C.
Publication
Washington, D.C. : 2006
ISSN
0036-8075
1095-9203
Volume/pages
312 :5770 (2006) , p. 117-121
ISI
000236584400045
Full text (Publisher's DOI)
UAntwerpen
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 05.11.2018
Last edited 04.09.2021