Publication
Title
Ruthenium-catalyzed reductive arylation of N‐(2‐Pyridinyl)amides with isopropanol and arylboronate esters
Author
Abstract
A new three‐component reductive arylation of amides with stable reactants (iPrOH and arylboronate esters), making use of a 2‐pyridinyl (Py) directing group, is described. The N‐Py‐amide substrates are readily prepared from carboxylic acids and PyNH2, and the resulting N‐Py‐1‐arylalkanamine reaction products easily transformed into the corresponding chlorides by substitution of the HN‐Py group with HCl. The 1‐aryl‐1‐chloroalkane products allow substitution and cross‐coupling reactions; thereby, a general protocol for the transformation of carboxylic acids into a variety of functionalities is obtained. The Py‐NH2 by‐product can be recycled.
Language
English
Source (journal)
Angewandte Chemie: international edition in English. - Weinheim
Publication
Weinheim : 2019
ISSN
1433-7851
0570-0833
DOI
10.1002/ANIE.201810947
Volume/pages
58 :2 (2019) , p. 482-487
ISI
000454944900016
Pubmed ID
30380163
Full text (Publisher's DOI)
Full text (open access)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Project info
Partial placement of the NMR infrastructure for the structural elucidation of synthetic and natural substances.
Durable chemical processes for the synthesis of fine chemicals.
Synthesis of a-secondary alkylamines via reductive functionalization of amides.
Transition metal catalyzed transformation of amides.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 05.11.2018
Last edited 09.10.2023
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