Publication
Title
Synthesis of 1-aza-6,7-dehydrotropanes via copper(I)-catalyzed coupling of 5-chloropentan-2-one with hydrazines and terminal alkynes
Author
Abstract
A one-pot, three-component, Cu(I)-catalyzed coupling of primary hydrazines, 5-chloropentan-2-one, and terminal alkynes was developed. The resulting 1-aza-6,7-dehydrotropanes compose a new class of substances while related 1-azatropanes are scarcely described in literature and closely resemble tropane alkaloids. Hydrogenation of the double bond in 1-aza-6,7-dehydrotropanes triggered a rearrangement, involving a [1,3]-hydride shift, forming cyclic hydrazones.
Language
English
Source (journal)
Synlett : accounts and rapid communications in synthetic organic chemistry. - Stuttgart, 1989, currens
Publication
Stuttgart : 2018
ISSN
0936-5214 [print]
1437-2096 [online]
DOI
10.1055/S-0037-1611041
Volume/pages
29 :20 (2018) , p. 2643-2647
ISI
000452029700007
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 06.11.2018
Last edited 02.10.2024
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