Publication
Title
Simulations of a multipinhole SPECT collimator for Clinical Dopamine Transporter (DAT) imaging
Author
Abstract
SPECT imaging of the dopamine transporter (DAT) is used for diagnosis and monitoring progression of Parkinson's disease (PD), and differentiation of PD from other neurological disorders. The diagnosis is based on the DAT binding in the caudate and putamen structures in the striatum. We previously proposed a relatively inexpensive method to improve the detection and quantification of these structures for dual-head SPECT by replacing one of the fan-beam collimators with a specially designed multipinhole (MPH) collimator. In this paper, we developed a realistic model of the proposed MPH system using the GATE simulation package and verified the geometry with an analytic simulator. Point source projections from these simulations closely matched confirming the accuracy of the pinhole geometries. The reconstruction of a hot-rod phantom showed that 4.8-mm resolution is achievable. The reconstructions of the XCAT brain phantom showed clear separation of the putamen and caudate, which is expected to improve the quantification of DAT imaging and PD diagnosis. Using this GATE model, point spread functions modeling physical factors will be generated for use in reconstruction. Also, further improvements in geometry are being investigated to increase the sensitivity of this base system while maintaining a target spatial resolution of 4.5-5 mm.
Language
Dutch, English
Source (journal)
IEEE Transactions on Radiation and Plasma Medical Sciences
Publication
2018
ISSN
2469-7311
Volume/pages
2 :5 (2018) , p. 444-451
ISI
000456150700006
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 06.11.2018
Last edited 04.09.2021
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