Publication
Title
Risky sexual behavior among patients onlong-term antiretroviral therapy: a prospective cohort study in urban and rural Uganda
Author
Abstract
Background: While the effects of initiation of antiretroviral treatment (ART) on risky sexual behavior have been extensively studied, less is known about the long-term changes in risky sexual behavior over time in resource-poor settings. Methods: We conducted a secondary longitudinal analysis of one rural and one urban cohort of patients who initiated ART in Uganda between April 2004 and July 2007 followed up-to 2016. Data on sexual behavior were collected every 6 months for 3.5 years in individuals on ART >= 4 years (baseline) when a behavioral questionnaire was introduced. Risky sexual behavior was defined as sexual intercourse with >= 2 partners or inconsistent or no condom use in previous 6 months. We report characteristics overall, and by cohort. We used multivariable generalized estimating equations logistic regression to assess the effects of time on ART on risky sexual behavior. Results: Of 1012 participants, 402 (39.8%) were urban and 610 (60.2%) were rural residents. Mean age was 42.8 years (SD 8.5). Mean duration of follow-up was 51.3months (SD 15.3), but longer for urban than rural participants (64.5 vs 36.4months). Risky sexual behavior declined from 33.1% at baseline to 9.6% after 3.5years of follow-up in the rural cohort (p <= 0.01 for the test of trend) and was unchanged from 9.7% at baseline to 9.9% after 3.5years in the urban cohort (p = 0.51). Receiving care at a rural clinic (aOR 4.99, 95% CI 3.64-6.84); male gender (aOR 1.66, 95% CI 1.26-2.19) and being younger (aOR 5.60, 95% CI 3.80-8.25 for 18-34 years and aOR 2.34, 95% CI 1.74-3.14 for 35-44years) were associated with increased odds of risky sexual behavior. Not being married (aOR 0.25; 95% CI 0.19-0.34), and longer time on ART (aOR 0.71 95% CI 0.67-0.76) were associated with reduced odds of risky sex. Conclusions: We observed a decline in risky sexual behavior in rural people on long-term (>= 4 years) ART. Rural, male and young individuals had higher odds of self-reported risky sexual behavior. ART programs should continue to emphasize risk reduction practices, especially among people receiving care in rural health facilities, males, younger individuals and those who are married.
Language
English
Source (journal)
Aids research and therapy. - London
Publication
London : 2018
ISSN
1742-6405
DOI
10.1186/S12981-018-0203-1
Volume/pages
15 (2018) , 9 p.
Article Reference
15
ISI
000447840000002
Pubmed ID
30340608
Medium
E-only publicatie
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 09.11.2018
Last edited 02.10.2024
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