Publication
Title
Economic evaluation of S. boulardii CNCM 1-745 for prevention of antibiotic-associated diarrhoea in hospitalized patients
Author
Abstract
Interest in administration of probiotics to prevent antibiotic-associated diarrhoea (AAD) in hospitalized patients is increasing. We determined the cost of antibiotic-associated diarrhoea in hospital settings for non-complicated and Clostridium difficile (C.diff) complicated AAD, and performed a health-economic analysis of AAD prevention with S. boulardii CNCM I-745 (S. boulardii) from data collected in 1 university and 3 regional hospitals in Flanders. Using a decision tree analytic model, costs and effects of S. boulardii for AAD prevention are calculated. Incremental costs due to AAD, including increased length of hospitalization, were calculated using bottom-up and top-down costing approaches from a hospital, healthcare payer (HCP) and societal perspective. Model robustness was tested using sensitivity analyses. Additional costs per hospitalized patient range from (sic) 277.4 (hospital) to (sic) 2,150.3 (societal) for non-complicated and from (sic) 588.8 (hospital) to (sic) 2,239.1 (societal) for C. diff. complicated AAD. Using S. boulardii as AAD prevention results in cost savings between (sic) 503 (bottom-up) and (sic) 28.1 (top-down) per patient treated with antibiotics from the HCP perspective; and (sic) 95.2 and (sic) 14.7 per patient from the societal and hospital perspectives. Our analysis shows the potential for using S. boulardii as AAD prophylactic treatment in hospitalized patients. Based on 831,655 hospitalizations with antibiotic administration in 2014 and (sic) 503 cost saving per patient on antibiotics, generalized use of S. boulardii could result in total annual savings up to (sic) 41.8 million for the Belgian HCP.
Language
English
Source (journal)
Acta gastro-enterologica belgica. - Bruxelles, 1996 - 2007
Publication
Bruxelles : 2018
ISSN
1784-3227
Volume/pages
81 :2 (2018) , p. 269-276
ISI
000447228800004
Pubmed ID
30024698
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 09.11.2018
Last edited 11.09.2021
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