Publication
Title
Assessment of acute and subacute toxicity of aqueous extract and in vitro susceptiblity of extracts and isolated indoloquinoline alkaloids from Cryptolepis sanguinolenta (lindl.) Schlechter (periplocaceae) root bark to Entamoeba histolytica
Author
Abstract
Aqueous and 80% methanol extracts from Cryptolepis sanguinolenta root bark and their alkaloids were submitted to an evaluation for their potential amoebicidal activity against Entamoeba histolytica. Results indicated that aqueous and 80% methanol extracts exhibited pronounced amoebicidal activity with minimal amoebicidal concentrations (MAC) of 6.25 and 4.15 μg/ml respectively and with inhibitory concentrations 50 (IC50) of 4.02 and 2.87 μg/ml respectively. Among isolated indoloquinoline alkaloids, cryptolepine, the major alkaloid of this plant part and its isomer neocryptolepine showed pronounced amoebicidal activity with MAC values of 3.12 and 1.87 μg/ml, and IC50 values of 3.27 and 2.07 μg/ml respectively. Other monomeric alkaloids such as cryptolepine HCl, hydrocryptolepine and quindoline displayed this activity with MAC and IC50 values ranging from 4.25 to 10.68 μg/ml with quindoline exhibing weak activity (MAC = 10.68 and IC50 =.8.65±0.03 μg/ml. The dimeric alkaloids biscryptolepine and cryptoquindoline also exhibited pronounced
Language
English
Source (journal)
World journal of pharmacy and pharmaceutical sciences
Publication
2018
Volume/pages
7 :7 (2018) , p. 183-210
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
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Research group
Publication type
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Affiliation
Publications with a UAntwerp address
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Identification
Creation 26.11.2018
Last edited 15.07.2021
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