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Title
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Assessment of acute and subacute toxicity of aqueous extract and in vitro susceptiblity of extracts and isolated indoloquinoline alkaloids from Cryptolepis sanguinolenta (lindl.) Schlechter (periplocaceae) root bark to Entamoeba histolytica
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Author
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Abstract
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| Aqueous and 80% methanol extracts from Cryptolepis sanguinolenta root bark and their alkaloids were submitted to an evaluation for their potential amoebicidal activity against Entamoeba histolytica. Results indicated that aqueous and 80% methanol extracts exhibited pronounced amoebicidal activity with minimal amoebicidal concentrations (MAC) of 6.25 and 4.15 μg/ml respectively and with inhibitory concentrations 50 (IC50) of 4.02 and 2.87 μg/ml respectively. Among isolated indoloquinoline alkaloids, cryptolepine, the major alkaloid of this plant part and its isomer neocryptolepine showed pronounced amoebicidal activity with MAC values of 3.12 and 1.87 μg/ml, and IC50 values of 3.27 and 2.07 μg/ml respectively. Other monomeric alkaloids such as cryptolepine HCl, hydrocryptolepine and quindoline displayed this activity with MAC and IC50 values ranging from 4.25 to 10.68 μg/ml with quindoline exhibing weak activity (MAC = 10.68 and IC50 =.8.65±0.03 μg/ml. The dimeric alkaloids biscryptolepine and cryptoquindoline also exhibited pronounced |
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Language
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English
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Source (journal)
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World journal of pharmacy and pharmaceutical sciences
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Publication
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2018
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Volume/pages
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7
:7
(2018)
, p. 183-210
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Full text (Publisher's DOI)
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Full text (open access)
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