Publication
Title
Quantitative CT analysis using functional imaging is superior in describing disease progression in idiopathic pulmonary fibrosis compared to forced vital capacity
Author
Abstract
BackgroundIdiopathic pulmonary fibrosis (IPF) is chronic fibrosing pneumonia with an unpredictable natural disease history. Functional respiratory imaging (FRI) has potential to better characterize this disease. The aim of this study was to identify FRI parameters, which predict FVC decline in patients with IPF.MethodsAn IPF-cohort (treated with pamrevlumab for 48weeks) was retrospectively studied using FRI. Serial CT's were compared from 66 subjects. Post-hoc analysis was performed using FRI, FVC and mixed effects models.ResultsLung volumes, determined by FRI, correlated with FVC (lower lung volumes with lower FVC) (R-2=0.61, p<0.001). A negative correlation was observed between specific image based airway radius (siRADaw) at total lung capacity (TLC) and FVC (R-2=0.18, p<0.001). Changes in FVC correlated significantly with changes in lung volumes (R-2=0.18, p<0.001) and siRADaw (R-2=0.15, p=0.002) at week 24 and 48, with siRADaw being more sensitive to change than FVC. Loss in lobe volumes (R-2=0.33, p<0.001), increasing fibrotic tissue (R-2=0.33, p<0.001) and airway radius (R-2=0.28, p<0.001) at TLC correlated with changes in FVC but these changes already occur in the lower lobes when FVC is still considered normal.ConclusionThis study indicates that FRI is a superior tool than FVC in capturing of early and clinically relevant, disease progression in a regional manner.
Language
English
Source (journal)
Respiratory research. - London
Publication
London : 2018
ISSN
1465-9921
1465-993X
Volume/pages
19 (2018) , 9 p.
Article Reference
213
ISI
000449470100002
Pubmed ID
30400950
Medium
E-only publicatie
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 10.12.2018
Last edited 15.10.2021
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