Publication
Title
How to modulate tumor hypoxia for preclinical in vivo imaging research
Author
Abstract
Tumor hypoxia is related with tumor aggressiveness, chemo-and radiotherapy resistance, and thus a poor clinical outcome. Therefore, over the past decades, every effort has been made to develop strategies to battle the negative prognostic influence of tumor hypoxia. For appropriate patient selection and follow-up, noninvasive imaging biomarkers such as positron emission tomography (PET) radiolabeled ligands are unprecedentedly needed. Importantly, before being able to implement these new therapies and potential biomarkers into the clinical setting, preclinical in vivo validation in adequate animal models is indispensable. In this review, we provide an overview of the different attempts that have been made to create differential hypoxic in vivo cancer models with a particular focus on their applicability in PET imaging studies.
Language
English
Source (journal)
Contrast media and molecular imaging. - Place of publication unknown
Publication
London : Wiley-hindawi , 2018
ISSN
1555-4309 [print]
1555-4317 [online]
Volume/pages
(2018) , 17 p.
Article Reference
UNSP 4608186
ISI
000448596300001
Pubmed ID
30420794
Medium
E-only publicatie
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 10.12.2018
Last edited 11.09.2021
To cite this reference