Title
Isolation, cDNA and genomic structure of a conserved new gene (NOF) at chromosome 11q13 next to FAU and oriented in the opposite transcriptional orientation Isolation, cDNA and genomic structure of a conserved new gene (NOF) at chromosome 11q13 next to FAU and oriented in the opposite transcriptional orientation
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
San Diego, Calif. ,
Subject
Biology
Human medicine
Engineering sciences. Technology
Source (journal)
Genomics: international journal of gene mapping and nucleotide sequencing. - San Diego, Calif.
Volume/pages
34(1996) :3 , p. 433-436
ISSN
0888-7543
ISI
A1996UU19100022
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
In our effort to characterize a gene at chromosome 11q13 involved in a t(11;17)(q13;q21) translocation in B-non-Hodgkin lymphoma, we have identified a novel human gene, NOF (Neighbour of FAU), It maps right next to FAU in a head to head configuration separated by a maximum of 146 nucleotides. cDNA clones representing NOF hybridized to a 2.2-kb mRNA present in all tissues tested. The largest open reading frame appeared to contain 166 amino acids and is proline rich, and the sequence shows no homology with any known gene in the public databases. The NOF gene consists of 4 exons and 3 introns spanning approximately 5 kb, and the boundaries between exons and introns follow the GT/AG rule. The NOF locus is conserved during evolution, with the predicted protein having over 80% identity to three translated mouse and rat ESTs of unknown function. Moreover, the mouse ESTs map in the same organization, closely linked to the FAU gene, in the mouse genome, NOF, however, is not affected by the t(11;17)(q13;q21) chromosomal translocation. (C) 1996 Academic Press, Inc.
E-info
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