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β-amyloid precursor protein and early-onset Alzheimer's disease
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| Author |
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| Abstract |
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| One of the major pathological hallmarks of Alzheimer's disease is the deposition in the brain parenchyma and cerebral blood vessel walls of amyloid beta-protein, a 4 kDa proteolytic product of the longer beta-amyloid precursor protein (APP). Six different single base mutations in the APP gene have been reported causing early-onset Alzheimer's disease (age at onset less than or equal to 65 years) or related amyloidosis in a small number of families. Cell transfection experiments using wild-type and mutant APP cDNA indicated that APP mutations result in the production of more or longer, aggregation prone, A beta peptides. | | |
| Language |
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English
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| Source (book) |
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The nature and origin of amyloid fibrils / Bock, G.R. [edit.] | |
| Publication |
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Chichester : Wiley, 1996
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| ISBN |
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0-471-96361-5
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| Volume/pages |
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p. 170-180
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| ISI |
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A1996BG31D00015
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