Title
β-amyloid precursor protein and early-onset Alzheimer's disease β-amyloid precursor protein and early-onset Alzheimer's disease
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
bookPart
Publication
Chichester :Wiley, [*]
Subject
Human medicine
Source (book)
The nature and origin of amyloid fibrils / Bock, G.R. [edit.]
ISBN - Hoofdstuk
0-471-96361-5
ISI
A1996BG31D00015
Carrier
E
Target language
English (eng)
Affiliation
University of Antwerp
Abstract
One of the major pathological hallmarks of Alzheimer's disease is the deposition in the brain parenchyma and cerebral blood vessel walls of amyloid beta-protein, a 4 kDa proteolytic product of the longer beta-amyloid precursor protein (APP). Six different single base mutations in the APP gene have been reported causing early-onset Alzheimer's disease (age at onset less than or equal to 65 years) or related amyloidosis in a small number of families. Cell transfection experiments using wild-type and mutant APP cDNA indicated that APP mutations result in the production of more or longer, aggregation prone, A beta peptides.
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