Publication
Title
β-amyloid precursor protein and early-onset Alzheimer's disease
Author
Abstract
One of the major pathological hallmarks of Alzheimer's disease is the deposition in the brain parenchyma and cerebral blood vessel walls of amyloid beta-protein, a 4 kDa proteolytic product of the longer beta-amyloid precursor protein (APP). Six different single base mutations in the APP gene have been reported causing early-onset Alzheimer's disease (age at onset less than or equal to 65 years) or related amyloidosis in a small number of families. Cell transfection experiments using wild-type and mutant APP cDNA indicated that APP mutations result in the production of more or longer, aggregation prone, A beta peptides.
Language
English
Source (book)
The nature and origin of amyloid fibrils / Bock, G.R. [edit.]
Publication
Chichester : Wiley, 1996
ISBN
0-471-96361-5
Volume/pages
p. 170-180
ISI
A1996BG31D00015
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 08.10.2008
Last edited 07.09.2017
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