Publication
Title
Large and fast human pyramidal neurons associate with intelligence
Author
Abstract
It is generally assumed that human intelligence relies on efficient processing by neurons in our brain. Although grey matter thickness and activity of temporal and frontal cortical areas correlate with IQ scores, no direct evidence exists that links structural and physiological properties of neurons to human intelligence. Here, we find that high IQ scores and large temporal cortical thickness associate with larger, more complex dendrites of human pyramidal neurons. We show in silico that larger dendritic trees enable pyramidal neurons to track activity of synaptic inputs with higher temporal precision, due to fast action potential kinetics. Indeed, we find that human pyramidal neurons of individuals with higher IQ scores sustain fast action potential kinetics during repeated firing. These findings provide the first evidence that human intelligence is associated with neuronal complexity, action potential kinetics and efficient information transfer from inputs to output within cortical neurons.
Language
English
Source (journal)
eLife
eLife
Publication
2018
ISSN
2050-084X
Volume/pages
7 (2018) , 21 p.
Article Reference
41714
e41714
ISI
000457827000001
Pubmed ID
30561325
Medium
E-only publicatie
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Project info
HBP: The Human Brain Project
Stochastic Assemblies in Spiking Neural Networks.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 19.12.2018
Last edited 19.10.2021
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