Publication
Title
Metformin : a candidate drug for renal diseases
Author
Abstract
Over the past decades metformin has been the optimal first-line treatment for type 2 diabetes mellitus (T2DM). Only in the last few years, it has become increasingly clear that metformin exerts benign pleiotropic actions beyond its prescribed use and ongoing investigations focus on a putative beneficial impact of metformin on the kidney. Both acute kidney injury (AKI) and chronic kidney disease (CKD), two major renal health issues, often result in the need for renal replacement therapy (dialysis or transplantation) with a high socio-economic impact for the patients. Unfortunately, to date, effective treatment directly targeting the kidney is lacking. Metformin has been shown to exert beneficial effects on the kidney in various clinical trials and experimental studies performed in divergent rodent models representing different types of renal diseases going from AKI to CKD. Despite growing evidence on metformin as a candidate drug for renal diseases, in-depth research is imperative to unravel the molecular signaling pathways responsible for metformins renoprotective actions. This review will discuss the current state-of-the-art literature on clinical and preclinical data, and put forward potential cellular mechanisms and molecular pathways by which metformin ameliorates AKI/CKD. View Full-Text Keywords: metformin; type 2 diabetes mellitus; acute kidney injury; chronic kidney disease; lactic acidosis; renoprotection; AMP-activated protein kinase pathway
Language
English
Source (journal)
International journal of molecular sciences
Publication
Basel : Mdpi , 2019
ISSN
1422-0067
1661-6596
Volume/pages
20 :1 (2019) , 15 p.
Article Reference
42
ISI
000459747700042
Pubmed ID
30583483
Medium
E-only publicatie
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Project info
The use of metformin in the battle against chronic kidney disease and its cardiovascular complications.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 07.01.2019
Last edited 17.10.2021
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