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Title
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Relation between mitochondrial DNA hyperdiversity, mutation rate and mitochondrial genome evolution in Melarhaphe neritoides (Gastropoda: Littorinidae) and other Caenogastropoda
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Author
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Abstract
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| Mitochondrial DNA hyperdiversity is primarily caused by high mutation rates (mu) and has potential implications for mitogenome architecture and evolution. In the hyperdiverse mtDNA of Melarhaphe neritoides (Gastropoda: Littorinidae), high mutational pressure generates unusually large amounts of synonymous variation, which is expected to (1) promote changes in synonymous codon usage, (2) reflect selection at synonymous sites, (3) increase mtDNA recombination and gene rearrangement, and (4) be correlated with high mtDNA substitution rates. The mitogenome of M. neritoides was sequenced, compared to closely related littorinids and put in the phylogenetic context of Caenogastropoda, to assess the influence of mtDNA hyperdiversity and high mu on gene content and gene order. Most mitogenome features are in line with the trend in Mollusca, except for the atypical secondary structure of the methionine transfer RNA lacking the T Psi C-loop. Therefore, mtDNA hyperdiversity and high mu in M. neritoides do not seem to affect its mitogenome architecture. Synonymous sites are under positive selection, which adds to the growing evidence of non-neutral evolution at synonymous sites. Under such non-neutrality, substitution rate involves neutral and non-neutral substitutions, and high mu is not necessarily associated with high substitution rate, thus explaining that, unlike high mu, a high substitution rate is associated with gene order rearrangement. |
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Language
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English
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Source (journal)
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Scientific reports. - London, 2011, currens
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Publication
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London
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Nature Publishing Group
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2018
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ISSN
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2045-2322
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DOI
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10.1038/S41598-018-36428-7
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Volume/pages
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8
(2018)
, 12 p.
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Article Reference
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17964
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ISI
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000453768800001
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Pubmed ID
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30568252
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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