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Title
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In vitro antiprotozoal activity of some medicinal plants against sleeping sickness, Chagas disease and leishmaniasis
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Author
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Abstract
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| Aim: Antiprotozoal activity of 36 medicinal plants was evaluated. Materials & methods:In vitro potency against Trypanosoma brucei brucei, T. b. rhodesiense, T. cruzi and Leishmania infantum beside cytotoxicity on MRC-5 fibroblasts were determined. Results & conclusion:Maytenus parviflora showed the highest activity against T. b. brucei (IC50 of 0.6g/ml) and T. b. rhodesiense (IC50 of 0.5g/ml) with low cytotoxicity (CC50 of 30g/ml). Saussureacostus and Commiphora wightii, showed pronounced potency against T. cruzi with an IC50 of 3.6 and 2.5g/ml, respectively. Jatropha pelargonifolia and Solanum villosum exhibited pronounced activity toward L. infantum with an IC50 of 3.2 and 2.0g/ml, respectively. M. parviflora, S. costus, C. wightii, J. pelargonifolia and S. villosum showed relevant selectivity. |
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Language
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English
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Source (journal)
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Future Medicinal Chemistry. - London, 2009, currens
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Publication
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London
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Future Science Ltd
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2018
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ISSN
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1756-8927
1756-8919
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DOI
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10.4155/FMC-2018-0180
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Volume/pages
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10
:22
(2018)
, p. 2607-2617
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ISI
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000453933400005
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Pubmed ID
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30511591
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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