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Title
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Restricted access volatile supramolecular solvents for single-step extraction/cleanup of benzimidazole anthelmintic drugs in milk prior to LC-MS/MS
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Author
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Abstract
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| In this work, a restricted access volatile supramolecular solvent (RAM-VOL-SUPRAS) directly synthesized in milk is proposed for the first time for the simultaneous extraction and cleanup of benzimidazole anthelmintic drugs in milk meant for human consumption. The RAM-VOL-SUPRAS was formed by the self-assembly and coacervation of hexanol in tetrahydrofuran induced by the water content in milk. Benzimidazoles legislated by the European Union were quantitatively extracted (80-110%), and proteins were precipitated by the action of THF and the amphiphile; extraction of carbohydrates was avoided by a size exclusion mechanism, and lipids were removed during hexanol evaporation. The analytical methodology was fully validated according to Commission Decision 2002/657/EC. Method detection limits from 0.03 to 0.14 mu g L-1 were well below the maximum residue limits legislated in milk for these drugs, with interday precisions at maximum residue levels below 13%. This novel methodology guarantees a rapid and reliable tool for daily and routine laboratory analyses in the field of food quality control. |
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Language
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English
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Source (journal)
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Journal of agricultural and food chemistry. - Washington, D.C.
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Publication
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Washington, D.C.
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2019
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ISSN
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0021-8561
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DOI
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10.1021/ACS.JAFC.8B06003
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Volume/pages
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67
:1
(2019)
, p. 520-530
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ISI
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000455561500055
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Pubmed ID
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30516988
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Full text (Publisher's DOI)
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