|
Title
|
|
|
|
Antiplasmodial prenylated flavonoids from stem bark of Erythrina latissima
|
|
|
Author
|
|
|
|
|
|
|
Abstract
|
|
|
|
| The antiplasmodial activity against Plasmodium falciparum strain K1 as well as cytotoxicity against MRC-5 cells of 15 prenylated flavonoids obtained from Erythrina latissima E. Mey (Leguminosae) from South Africa was determined. Although initially some promising activities were observed, with 5′-prenyl-pratensein being the most selective compound, most IC50 values varied from 1 to 30 μM, with cytotoxicities in the same range, resulting in selectivity indices <10. The prenylated flavonoid scaffold can be considered as a promising skeleton for antiplasmodial compounds, but structural modifications to reduce the cytotoxiciy and to improve the selectivity will be necessary. |
|
|
|
Language
|
|
|
|
English
|
|
|
Source (journal)
|
|
|
|
Phytochemistry letters
|
|
|
Publication
|
|
|
|
2019
|
|
|
ISSN
|
|
|
|
1874-3900
|
|
|
DOI
|
|
|
|
10.1016/J.PHYTOL.2019.02.001
|
|
|
Volume/pages
|
|
|
|
30
(2019)
, p. 169-172
|
|
|
ISI
|
|
|
|
000461363900033
|
|
|
Full text (Publisher's DOI)
|
|
|
|
|
|
|
Full text (open access)
|
|
|
|
|
|
|
Full text (publisher's version - intranet only)
|
|
|
|
|
|