|
Title
|
|
|
|
Relative cerebral flow from dynamic PIB scans as an alternative for FDG scans in Alzheimer's disease PET studies
| |
|
Author
|
|
|
|
| |
|
Abstract
|
|
|
|
| In Alzheimer's Disease (AD) dual-tracer positron emission tomography (PET) studies with 2-[F-18]-fluoro-2-deoxy-D-glucose (FDG) and C-11-labelled Pittsburgh Compound B (PIB) are used to assess metabolism and cerebral amyloid-beta deposition, respectively. Regional cerebral metabolism and blood flow (rCBF) are closely coupled, both providing an index for neuronal function. The present study compared PIB-derived rCBF, estimated by the ratio of tracer influx in target regions relative to reference region (R-1) and early-stage PIB uptake (ePIB), to FDG scans. Fifteen PIB positive (+) patients and fifteen PIB negative (-) subjects underwent both FDG and PIB PET scans to assess the use of R-1 and ePIB as a surrogate for FDG. First, subjects were classified based on visual inspection of the PIB PET images. Then, discriminative performance (PIB+ versus PIB-) of rCBF methods were compared to normalized regional FDG uptake. Strong positive correlations were found between analyses, suggesting that PIB-derived rCBF provides information that is closely related to what can be seen on FDG scans. Yet group related differences between method's distributions were seen as well. Also, a better correlation with FDG was found for R-1 than for ePIB. Further studies are needed to validate the use of R-1 as an alternative for FDG studies in clinical applications. |
| |
|
Language
|
|
|
|
English
| |
|
Source (journal)
|
|
|
|
PLoS ONE
| |
|
Publication
|
|
|
|
2019
| |
|
ISSN
|
|
|
|
1932-6203
| |
|
DOI
|
|
|
|
10.1371/JOURNAL.PONE.0211000
| |
|
Volume/pages
|
|
|
|
14
:1
(2019)
, 19 p.
| |
|
Article Reference
|
|
|
|
e0211000
| |
|
ISI
|
|
|
|
000456015500096
| |
|
Pubmed ID
|
|
|
|
30653612
| |
|
Medium
|
|
|
|
E-only publicatie
| |
|
Full text (Publisher's DOI)
|
|
|
|
| |
|
Full text (open access)
|
|
|
|
| |
|