|
Title
|
|
|
|
Two new antiplasmodial flavonolignans from the leaves of Cecropia obtusifolia
|
|
|
Author
|
|
|
|
|
|
|
Abstract
|
|
|
|
| Cecropia species are traditionally used in several Latin American countries to treat various diseases including malaria. A phytochemical investigation on the leaves of Cecropia obtusifolia Bertol (Urticaceae) afforded two new flavonolignans, i.e. ent-mururin A (1) and ent-vaccinin A (2). They were isolated by means of chromatographic techniques and elucidated based on their spectroscopic (NMR, MS and optical rotation) data, and were described as new isomers of mururin A and vaccinin A. Antiplasmodial evaluation revealed that 1 and 2 were moderately active in vitro against the chloroquine-resistant strain Plasmodium falciparum K1 (IC50 4.68 μM and 7.34 μM, respectively) without cytotoxic effects up to a concentration of 64.0 μM. |
|
|
|
Language
|
|
|
|
English
|
|
|
Source (journal)
|
|
|
|
Phytochemistry letters
|
|
|
Publication
|
|
|
|
2019
|
|
|
ISSN
|
|
|
|
1874-3900
|
|
|
DOI
|
|
|
|
10.1016/J.PHYTOL.2019.03.019
|
|
|
Volume/pages
|
|
|
|
31
(2019)
, p. 118-120
|
|
|
ISI
|
|
|
|
000469429200021
|
|
|
Full text (Publisher's DOI)
|
|
|
|
|
|
|
Full text (open access)
|
|
|
|
|
|
|
Full text (publisher's version - intranet only)
|
|
|
|
|
|