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Title
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The genomics of major psychiatric disorders in a large pedigree from Northern Sweden
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Author
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Abstract
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| We searched for genetic causes of major psychiatric disorders (bipolar disorder, schizoaffective disorder, and schizophrenia) in a large, densely affected pedigree from Northern Sweden that originated with three pairs of founders born around 1650. We applied a systematic genomic approach to the pedigree via karyotyping (N = 9), genome-wide SNP arrays (N = 418), whole-exome sequencing (N = 26), and whole-genome sequencing (N = 10). Comprehensive analysis did not identify plausible variants of strong effect. Rather, pedigree cases had significantly higher genetic risk scores compared to pedigree and community controls. |
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Language
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English
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Source (journal)
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Translational psychiatry. - New York, NY, 2011, currens
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Publication
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New York, NY
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Nature Pub. Group
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2019
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ISSN
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2158-3188
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DOI
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10.1038/S41398-019-0414-9
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Volume/pages
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9
(2019)
, 8 p.
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Article Reference
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60
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ISI
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000459834400001
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Pubmed ID
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30718465
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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