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Title
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Outcome of infants with therapeutic hypothermia after perinatal asphyxia and early-onset sepsis
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Author
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Abstract
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| Background: Animal models suggest that neuroprotective effects of therapeutic hypothermia (TH) after perinatal asphyxia are reduced in infants with early-onset sepsis. Objectives: To assess the outcome of infants with perinatal asphyxia, neonatal encephalopathy, and TH in the presence of early-onset sepsis. Methods: In a retrospective cohort of 1,084 infants with perinatal asphyxia and TH, the outcome of 42 infants (gestational age 36.1-42.6 weeks and birth weight 2,280-5,240 g) with proven sepsis (n = 14) and probable sepsis (n = 28) was analyzed. Death, cerebral palsy, or a delayed development at 2 years was considered an adverse outcome. Results: Sepsis was caused mostly by group B streptococci (n = 17), other Gram-positive bacteria (n = 5), and Candida albicans (n = 1). Of the 42 infants, 9 (21.4%) died, and 5 (11.9%) showed impairments on follow-up. The outcome is comparable to the previously reported outcome of infants with TH without early-onset sepsis. Conclusion: A good outcome was reported in the majority of infants with perinatal asphyxia, TH, and early-onset sepsis. Cooling should not be withheld from these infants. (c) 2018 The Author(s) Published by S. Karger AG, Basel |
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Language
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English
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Source (journal)
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Neonatology
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Publication
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2019
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ISSN
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1661-7800
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DOI
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10.1159/000493358
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Volume/pages
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115
:2
(2019)
, p. 127-133
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ISI
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000460983200004
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Pubmed ID
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30419568
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Full text (Publisher's DOI)
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Full text (open access)
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