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Title
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Clinical- and surgery-specific risk factors for post-operative sepsis : a systematic review and meta-analysis of over 30 million patients
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Author
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Abstract
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| Post-operative sepsis is a severe complication of surgery, which often worsens the clinical outcomes. While several risk factors have been identified, the importance of others remains uncertain. This systematic review and meta-analysis aimed to determine patient and surgery-related risk factors for post-operative sepsis. We reviewed Medline, the Web of Science, and the Cochrane library, systematically, for articles describing risk factors for sepsis. The role of eligible risk factors was investigated using a random-effects model, while analyzing univariate and multivariate data separately. Among 193 pro- and retrospective articles, comprising over 30 million patients, 38 eligible risk factors were selected for this meta-analysis. The patient-related risk factors associated with post-operative sepsis included male gender (odds ratio, OR 1.41), pre-existing heart failure (OR 2.53), diabetes (OR 1.41), and chronic kidney disease (OR 1.26). The surgery-related risk factors identified included emergency surgery (OR 3.38), peri-operative blood transfusion (OR 1.90), inpatient hospital stay (OR 2.31), and open surgery (OR 1.80). The adjusted overall incidence of surgical sepsis was 1.84%. In conclusion, multiple-patient and surgery-related risk factors are associated with the development of post-operative sepsis. Recognizing these risk factors could assist in the pre-operative identification of patients at risk of post-operative sepsis. |
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Language
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English
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Source (journal)
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Surgery today. - Berlin
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Publication
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New york
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Springer
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2020
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ISSN
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0941-1291
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DOI
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10.1007/S00595-019-01827-4
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Volume/pages
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50
:5
(2020)
, p. 427-439
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ISI
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000528524300001
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Pubmed ID
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31172283
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Full text (Publisher's DOI)
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Full text (open access)
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Full text (publisher's version - intranet only)
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