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Title
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In vitro and ex vivo assessment of microporous Faujasite zeolite (NaX-FAU) as a carrier for the oral delivery of danazol
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Author
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Abstract
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| Microporous zeolite NaX-FAU has been systemically evaluated for the oral delivery of the poorly water-soluble compound danazol. For this purpose, danazol-loaded zeolitic particles were prepared by the incipient wetness method and were characterized by means of N-2 physisorption, X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and high-resolution transmission electron microscopy (HRTEM). The zeolitic formulation shows a high drug payload and drug stability over a period of six months under accelerated storage conditions. The dissolution profile of danazol-loaded zeolitic particles was assessed in simulated gastric fluid (SGF) pH 1.2; fasted state simulated intestinal fluids (FaSSIF) and fed state simulated intestinal fluid (FeSSIF) showing a gradual and increasing drug dissolution in the different media. Ex vivo studies using the everted gut sac model show an increased drug transport across rat intestinal epithelium when loaded in the zeolitic particles. Our results suggest that microporous Faujasite zeolite (NaX-FAU) could be used as a drug delivery system to facilitate the oral delivery of poorly water soluble compounds. |
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Language
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English
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Source (journal)
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Journal of drug delivery science and technology / Academy of Pharmaceutical Science and Technology [Tokyo]; Association de pharmacie galénique industrielle [Paris] - Paris, 2004, currens
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Publication
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Paris
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Editions de santé
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2019
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ISSN
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1773-2247
[print]
2588-8943
[online]
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DOI
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10.1016/J.JDDST.2019.02.036
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Volume/pages
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51
(2019)
, p. 177-184
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ISI
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000468750300018
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Full text (Publisher's DOI)
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Full text (open access)
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Full text (publisher's version - intranet only)
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