Publication
Title
Heart failure with preserved ejection fraction : a review of cardiac and noncardiac pathophysiology
Author
Abstract
Heart failure with preserved ejection fraction (HFpEF) is one of the largest unmet clinical needs in 21st-century cardiology. It is a complex disorder resulting from the influence of several comorbidities on the endothelium. A derangement in nitric oxide bioavailability leads to an intricate web of physiological abnormalities in the heart, blood vessels, and other organs. In this review, we examine the contribution of cardiac and noncardiac factors to the development of HFpEF. We zoom in on recent insights on the role of comorbidities and microRNAs in HFpEF. Finally, we address the potential of exercise training, which is currently the only available therapy to improve aerobic capacity and quality of life in HFpEF patients. Unraveling the underlying mechanisms responsible for this improvement could lead to new biomarkers and therapeutic targets for HFpEF.
Language
English
Source (journal)
Frontiers in physiology / Frontiers Research Foundation (Lausanne, Switzerland) - [Lausanne], 2010, currens
Publication
Lausanne : Frontiers media sa , 2019
ISSN
1664-042X
DOI
10.3389/FPHYS.2019.00638
Volume/pages
10 (2019) , 14 p.
Article Reference
638
ISI
000469452800001
Pubmed ID
31191343
Medium
E-only publicatie
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Project info
Identification of small molecule ErbB4 agonists for treatment of heart failure.
Activating the neuregulin-1/ErbB4 pathway for treatment of heart failure.
Studies of the ErbB4 receptor in myocardial non-myocytes to create new opportunities for the treatment of cardiac disease.
Effect of iron status and red cell indices on exercise capacity and response of exercise training
Diagnostic and therapeutic potential of microRNA-181c in HFpEF.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 25.06.2019
Last edited 02.10.2024
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